You can handle the page layout with the table tag:
Create a master page with this format :
your master file should look like this:
<%@ Master Language="C#" AutoEventWireup="true" CodeFile="MasterPage3.master.cs"
Inherits="MasterPage3" %>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml">
<head runat="server">
<title></title>
</head>
<body>
<form id="form1" runat="server">
<div>
<table runat="server">
<tr>
<td colspan="2">
logo of your website
</td>
</tr>
<tr>
<td>
Menus
</td>
<td>
<asp:ContentPlaceHolder ID="ContentPlaceHolder1" runat="server">
</asp:ContentPlaceHolder>
</td>
</tr>
<tr>
<td colspan="2">
Bottom menus
</td>
</tr>
</table>
</div>
</form>
</body>
</html>
Now add a content file By Right Click on the Master file -> Add Content Page
Or add new webForm and choose "Select master file" checkbox in the add new item dialogbox
Now your Child page look like this:
<%@ Page Title="" Language="C#" MasterPageFile="~/MasterPage3.master" AutoEventWireup="true" CodeFile="Default8.aspx.cs" Inherits="Default8" %>
<asp:Content ID="Content1" ContentPlaceHolderID="ContentPlaceHolder1" Runat="Server">
add your child page content or controls here
</asp:Content>
Hope you get it!